This week in MathOnco 317

Precision dosing, cell plasticity, evolutionary dynamics, and more...

“This week in Mathematical Oncology” — Jan 16, 2025

> mathematical-oncology.org

From the editor:

Today’s cover artwork is from Sarah Groves (https://smgroves.github.io), based on the excellent video she created answering the question “What is systems biology, and how is it related to mathematical oncology?”

Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

1. Mathematical multi-compartment modeling of chronic lymphocytic leukemia cell kinetics under ibrutinib
   Melanie Schulz, Sanne Bleser, Manouk Groels, Dragan Bošnački, Jan A. Burger, Nicholas Chiorazzi, Carsten Marr

2. Barriers and Facilitators for Bringing Model-Informed Precision Dosing to the Patient's Bedside: A Systematic Review
   Anna Caroline Dibbets, Charlotte Koldeweij, Esra P. Osinga, Hubertina C. J. Scheepers, Saskia N. de Wildt

3. From Fluctuations and Disorder to Scaling and Control: The Emergence of Resistance in Microbial Communities
   Jacob Moran, Kevin B. Wood

4. Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER
   Olivia Lucas, Sophia Ward, Rija Zaidi, Abigail Bunkum, …, Mariam Jamal-Hanjani, Nnennaya Kanu, Charles Swanton, Simone Zaccaria

5. Design principles of regulatory networks underlying epithelial mesenchymal plasticity in cancer cells
   Sarthak Sahoo, Kishore Hari, Mohit Kumar Jolly

6. Personalized predictions of Glioblastoma infiltration: Mathematical models, Physics-Informed Neural Networks and multimodal scans
   Ray Zirui Zhang, Ivan Ezhov, Michal Balcerak, Andy Zhu, Benedikt Wiestler, Bjoern Menze, John S. Lowengrub

7. Adaptive Treatment of Metastatic Prostate Cancer Using Generative Artificial Intelligence
   Youcef Derbal

8. Dynamic collateral sensitivity profiles highlight opportunities and challenges for optimizing antibiotic treatments
   Jeff Maltas ,Anh Huynh,Kevin B. Wood

1. Agent-based modeling reveals impacts of cell adhesion and matrix remodeling on cancer collective cell migration phenotypes
   Temitope O. Benson, Mohammad Aminul Islam, Kailei Liu, Ashlee N. Ford Versypt

2. Genealogies in Growing Solid Tumors
   Rick Durrett

1. The lives of cells, recorded
   Nature Reviews Genetics (Perspective)

2. Empowering biomedical discovery with AI agents
   Cell (Perspective)

3. Jana Gevertz

   Math Oncology Interviews by Thomas Hillen (YouTube)

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Based on the video: This is how we solve the problem of cancer

Mathematical Oncology Blog Post: What is systems biology, and how is it related to mathematical oncology?

Artist: Sarah Groves, @smgroves

Caption: Many cancer treatments today simply don't work. As part of an NIH-funded Center through the Cancer Systems Biology Consortium, I developed a video that explains why, and what systems biologists are doing to combat some of the most common problems with how we think about curing cancer.

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

2. Conferences / Meetings

• Workshop on cancer plasticity that will be held at the MPI in Plön, Germany, from May 19 to 22, 2025

3. Special issues

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