This week in MathOnco 347

Math oncology for high schoolers, IMO Workshop, and more...

“This week in Mathematical Oncology” — August 14, 2025

> mathematical-oncology.org

From the editor:

The annual IMO Workshop is approaching! Check out the artwork below advertising the workshop (if you’ve attended in the past, your picture might be featured?) and click this link to register: IMO Workshop 13.

If you’re in high school (or know someone who is), check out this resource on Math Oncology for high school students (hsmath-oncology.org), started by Isaac Jung!

Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

1. A mathematical model for cancer dynamics with treatment and saboteur bacteria
   Anna Geretovszky, Gergely Röst

2. Mathematical modeling and simulation of tumor-induced angiogenesis in retinal hemangioblastoma
   Franco Pradelli, Giovanni Minervini, Pradeep Venkatesh, Shorya Azad, Hector Gomez, Silvio C. E. Tosatto

3. Using Virtual Patients to Evaluate Dosing Strategies for Bispecifics With a Bell-Shaped Efficacy Curve
   Jana Gevertz, Irina Kareva

4. Evolution-Informed Modeling and Control of Tumor Growth
   Chiara Romano; Maria Domenica Di Benedetto; Alessandro Borri

5. Ecological graph theory: Simulating competition and coexistence on graphs
   Ata Kalirad, Ralf J. Sommer

6. Adaptive cancer therapy: can non-genetic factors become its achilles heel?
   Gábor Valcz, Robert A. Gatenby, Beáta Újvári, Edit I. Buzás & Béla Molnár

7. Cancer model with moving extinction threshold reproduces real cancer data
   Frank Bastian, Hassan Alkhayuon, Kieren Mulchrone, Micheal O’Riordain, Sebastian Maciej Wieczorek

8. Mechanistic modeling of metastatic relapse in early breast cancer to investigate the biological impact of prognostic biomarkers
   Célestin Bigarré, François Bertucci, Pascal Finetti, Gaëtan Macgrogan, Xavier Muracciole, Sébastien Benzekry

9. Parameter Estimation in Recurrent Tumor Evolution with Finite Carrying Capacity
   Kevin Leder, Zicheng Wang, Xuanming Zhang

1. A phenotype-structured reaction-diffusion model of avascular glioma growth
   Francesca Ballatore, Xinran Ruan, Chiara Giverso, Tommaso Lorenzi

2. Predicting Anatomical Brain Tumor Growth by Guided Denoising Diffusion Models
   Daria Laslo, Julia Wolleb, Maria Monzon, Raimund Kottke, …, Andreas M. Rauschecker, Sabine Mueller, Catherine Ruth Jutzeler, Sarah Brüningk

3. Mechanistic Learning with Guided Diffusion Models to Predict Spatio-Temporal Brain Tumor Growth
   Daria Laslo, Efthymios Georgiou, Marius George Linguraru, Andreas Rauschecker, Sabine Muller, Catherine R. Jutzeler, Sarah Bruningk

1. High School Mathematical Oncology

   Invitation for Students to Explore the Intersection of Math and Cancer Research

   Written by Isaac Jung - October 06, 2025
   ”The High School Mathematical Oncology website serves as a hub where students can explore resources, learn foundational concepts, and connect with others. I’ve compiled a collection of review articles, research publications, recommended introductory books, and links to cancer research centers involved in mathematical oncology. I’ve also made Google Slides presentations on key topics such as the Hallmarks of Cancer and other basic cancer biology. My hope is that other students who have participated in research projects can contribute by sharing their projects and create educational content that makes complex mathematical oncology ideas easier to understand. Looking ahead, I’d love for the site to grow into a platform that also offers mentorship opportunities and a peer-support network.”

The newsletter now has a dedicated homepage where we post the cover artwork for each issue, curated by Maximilian Strobl, Sarah Groves, and Veronika Hofmann. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Based on: The IMO Workshop 13 - Treatment Revolution

Artist: Chandler Gatenbee, Jill Gallaher, Sandy Anderson

Caption: The IMO workshop, hosted by the Moffitt Cancer Center, is designed to motivate and facilitate hands-on modeling experience to drive real-world clinical impact. This year’s focus – the 13^th edition – will be the development of innovative future generation cancer treatments - a treatment revolution. During the workshop participants are divided into multiple teams combining clinical, experimental and theoretical members, who will integrate their energies to address questions such as: (i)Exploiting the potential role of treatment breaks (ii) Integrating microenvironment modulating therapies (iii) Using sparse and discrete data to facilitate treatment decisions (iv) How best to exploit immunotherapy in combination with other drugs, or (v) How can we model disease when quantifiable burden exists. The teams get 4.5 days to to come up with a model, solve it and give a presentation - with a chance to win a $50K pilot grant (generously funded by Moffitt Cancer Center) to the leaders of the winning team. To learn more, check out our webpage, and follow-along in the action on X, LinkedIn, or BlueSky.

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

2. Conferences / Meetings

• Inaugural Meeting - Cancer Population Genetics Club (CANPOP): Monday 1st December from 1-5pm at the Institute of Cancer Research in Chelsea (123 Old Brompton Road, London SW7 3RP; Nearest Tube: Gloucester Rd). Register here.

3. Special issues

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