This week in MathOnco 218

Immunotherapy, “oncostreams”, Fisher-Kolmogorov models, evolutionary scales, and more

“This week in Mathematical Oncology” — July 14, 2022

> mathematical-oncology.org

From the editor:

Today we feature articles on immunotherapy, “oncostreams”, Fisher-Kolmogorov models, evolutionary scales, and more. Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

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"The outcome of the peer review process is a random variable whose mean is determined by the quality of the paper and whose variance is determined by the quality of the referees."
- Author Unknown1

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1. Rethinking the immunotherapy numbers game
   Rebecca A Bekker, Mohammad U Zahid, Jennifer M Binning, Bryan Q Spring, Patrick Hwu, Shari Pilon-Thomas, Heiko Enderling

2. Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression
   Andrea Comba, Syed M. Faisal, Patrick J. Dunn, Anna E. Argento, …, Celina G. Kleer, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein

3. Data-Driven Simulation of Fisher-Kolmogorov Tumor Growth Models Using Dynamic Mode Decomposition
   Alex Viguerie, Malú Grave, Gabriel F. Barros, Guillermo Lorenzo, Alessandro Reali, Alvaro Coutinho

4. Questions to guide cancer evolution as a framework for furthering progress in cancer research and sustainable patient outcomes
   Jason A. Somarelli, James DeGregori, Marco Gerlinger, Henry H. Heng, Andriy Marusyk, Danny R. Welch, Frank H. Laukien

5. Delaying Emergence of Resistance to KRAS Inhibitors with Adaptive Therapy: “Treatment-to-Contain” Instead of “Treatment-to-Cure”
   Amir Imran Faisal Hamdi, Johnson Stanslas

6. Scales of Cancer Evolution: Selfish Genome or Cooperating Cells?
   Branislav Brutovský

1. A Quantitative Characterization of the Spatial Distribution of Brain Metastases from Breast Cancer and Respective Molecular Subtypes
   Saeedeh Mahmoodifar, Dhiraj J. Pangal, Tyler Cardinal, David Craig, Thomas Simon, Ben Yi Tew, Wensha Yang, Eric Chang, Min Yu, Josh Neman, Jeremy Mason, Arthur Toga, Bodour Salhia, Gabriel Zada, Paul K. Newton

2. High accuracy indicators of androgen suppression therapy failure for prostate cancer – a modeling study
   William Meade, Allison Weber, Tin Phan, Emily Hampston, Laura Figueroa Resa, John Nagy, Yang Kuang

1. MathOnco Research Group Highlights
   Saskia Haupt: We have launched a new feature for the MathOnco website: MathOnco Research Group Highlights. In this section of the website, we provide a world-wide overview of MathOnco research groups (https://mathematical-oncology.org/groups), that can be searched by keywords and geographic location.

2. A Beginner's Introduction to Mixed Effects Models
   Meghan Hall

3. Evolutionary Therapy
   Please consider reading and contributing this new Wikipedia page!

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.

Caption: “Have you ever wanted to visualize a histogram or density from counts of (x,y) pairs? Say if you wanted take a slice through a 2-dimensional density function along an arbitrary (non-linear) path? Look no further! Originally, the term ‘histo’ means mast, as in a sailboat mast that holds the luff of a sail. Here we call these a curvogram, which is a histogram on a curve that is given by a user defined function. To create these, orientated the bins so that they are perpendicular to the curve and performed a coordinate transform to ensure the edges are perpendicular to the curve at every point. To try this out yourself and help us develop this idea, you can find a MATLAB and Python version of our code here.“

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