This week in MathOnco 220

Bet-hedging, phenotypic plasticity, spatial profiling, multilevel selection, somatic evolution and more.

“This week in Mathematical Oncology” — July 28, 2022

> mathematical-oncology.org

From the editor:

Today we feature articles on bet-hedging, phenotypic plasticity, spatial profiling, multilevel selection, somatic evolution and more.

Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

---

"With four parameters I can fit an elephant, and with five I can make him wiggle his trunk."
- von Neumann, on complicated math models1

---

1. From developmental to atavistic bet-hedging: How cancer cells pervert the exploitation of random single-cell phenotypic fluctuations
   Jean-Pascal Capp, Frédéric Thomas

2. Robustness in phenotypic plasticity and heterogeneity patterns enabled by EMT networks
   Anish Hebbar, Ankush Moger, Kishore Hari, Mohit Kumar Jolly

3. A general theory for temperature dependence in biology
   José Ignacio Arroyo, Beatriz Díez, Christopher P. Kempes, Geoffrey B. West, Pablo A. Marquet

4. The emerging landscape of spatial profiling technologies
   Jeffrey R. Moffitt, Emma Lundberg, Holger Heyn

5. Game of clones: Battles in the field of carcinogenesis
   Zahraa Rahal, Ansam Sinjab, Ignacio I. Wistuba, Humam Kadara

6. Long-time behavior of a PDE replicator equation for multilevel selection in group-structured populations
   Daniel B. Cooney, Yoichiro Mori

1. Automatic detection of spatio-temporal signalling patterns in cell collectives
   Paolo Armando Gagliardi, Benjamin Grädel, Marc-Antoine Jacques, Lucien Hinderling, …, Gerald Kastberger, Olivier Pertz, Maciej Dobrzyński

2. Building pyramids against the evolutionary emergence of pathogens
   Sylvain Gandon, Martin Guillemet, François Gatchitch, Antoine Nicot, Ariane C. Renaud, Denise M. Tremblay, Sylvain Moineau

1. Somatic evolution: We contain multitudes
   Ruxandra Tesloianu

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.

Caption: Heterogeneity is a landmark of glioblastoma tumors. How such heterogeneity is set up remains unknown. We recently discovered the existence of “oncostreams”, active multicellular accumulations of elongated and aligned cells which display mesenchymal properties, and migrate throughout the tumor and along invasive borders. Furthermore, “oncostreams” can carry  immune cells such as macrophages and microglia, and their structure and function depends on Collagen I. We believe “oncostreams” are essential to establishing glioblastoma cellular and molecular heterogeneity. To learn more, read our papers here [1, 2, 3].

Created by: Andrea Comba, Pedro Lowenstein & Maximilian Strobl

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

• Research Fellowship in Industrial and Interdisciplinary Mathematics (Fabian Spill)

• Research Fellowship in Industrial and Interdisciplinary Mathematics (Fabian Spill)

• Research Fellow Position at The University of Michigan, USA (Pedro Lowenstein, University of Michigan)

2. Conferences / Meetings

3. Special issues

---

Current subscriber count: >1.25k

1. See here.