This week in MathOnco 220
Bet-hedging, phenotypic plasticity, spatial profiling, multilevel selection, somatic evolution and more.
“This week in Mathematical Oncology” — July 28, 2022
From the editor:
Today we feature articles on bet-hedging, phenotypic plasticity, spatial profiling, multilevel selection, somatic evolution and more.
"With four parameters I can fit an elephant, and with five I can make him wiggle his trunk."
- von Neumann, on complicated math models1
From developmental to atavistic bet-hedging: How cancer cells pervert the exploitation of random single-cell phenotypic fluctuations
Jean-Pascal Capp, Frédéric Thomas
Robustness in phenotypic plasticity and heterogeneity patterns enabled by EMT networks
Anish Hebbar, Ankush Moger, Kishore Hari, Mohit Kumar Jolly
A general theory for temperature dependence in biology
José Ignacio Arroyo, Beatriz Díez, Christopher P. Kempes, Geoffrey B. West, Pablo A. Marquet
The emerging landscape of spatial profiling technologies
Jeffrey R. Moffitt, Emma Lundberg, Holger Heyn
Game of clones: Battles in the field of carcinogenesis
Zahraa Rahal, Ansam Sinjab, Ignacio I. Wistuba, Humam Kadara
Long-time behavior of a PDE replicator equation for multilevel selection in group-structured populations
Daniel B. Cooney, Yoichiro Mori
Automatic detection of spatio-temporal signalling patterns in cell collectives
Paolo Armando Gagliardi, Benjamin Grädel, Marc-Antoine Jacques, Lucien Hinderling, …, Gerald Kastberger, Olivier Pertz, Maciej Dobrzyński
Building pyramids against the evolutionary emergence of pathogens
Sylvain Gandon, Martin Guillemet, François Gatchitch, Antoine Nicot, Ariane C. Renaud, Denise M. Tremblay, Sylvain Moineau
Somatic evolution: We contain multitudes
The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.
Caption: Heterogeneity is a landmark of glioblastoma tumors. How such heterogeneity is set up remains unknown. We recently discovered the existence of “oncostreams”, active multicellular accumulations of elongated and aligned cells which display mesenchymal properties, and migrate throughout the tumor and along invasive borders. Furthermore, “oncostreams” can carry immune cells such as macrophages and microglia, and their structure and function depends on Collagen I. We believe “oncostreams” are essential to establishing glioblastoma cellular and molecular heterogeneity. To learn more, read our papers here [1, 2, 3].
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