This week in MathOnco 222

Luria-Delbrück, spatial structures, lineage tracing, neoadjuvant chemo, mutation accumulation, and more…

“This week in Mathematical Oncology” — Aug. 11, 2022

> mathematical-oncology.org

From the editor:

Today we feature articles on Luria-Delbrück, spatial structures, lineage tracing, neoadjuvant chemo, mutation accumulation, and more.

Today’s cover artwork features another scientific newsletter, “Hot Topics in ML+Bio” written by Jacob Pettit — please consider subscribing today.

Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

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"Evolution forms the first principles of all cancer biology."
- Bob Gatenby

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1. Estimating the transfer rates of bacterial plasmids with an adapted Luria–Delbrück fluctuation analysis
   Olivia Kosterlitz, Adamaris Muñiz Tirado, Claire Wate, Clint Elg, Ivana Bozic, Eva M. Top, Benjamin Kerr

2. The role of spatial structures of tissues in cancer initiation dynamics
   Cade B Spaulding, Hamid Teimouri, Anatoly B Kolomeisky

3. A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy
   Sho Ueda, Satoshi Yamashita, Miho Nakajima, Tadashi Kumamoto, …, Yuichi Shiraishi, Masayuki Noguchi, Yukio Sato, Toshikazu Ushijima

4. “Fateful” encounter: Lineage tracing meets phylogeny to unravel mysteries of cancer progression
   Wing Hing Wong, Christina Curtis

5. MRI-based digital models forecast patient-specific treatment responses to neoadjuvant chemotherapy in triple-negative breast cancer
   Chengyue Wu, Angela M. Jarrett, Zijian Zhou, Nabil Elshafeey,…, Jong Bum Son, Jingfei Ma, Gaiane M. Rauch, Thomas E. Yankeelov

6. Growth dynamics of breast cancer stem cells: effects of self-feedback and EMT mechanisms
   Liuyong Pang, Sanhong Liu, Zhong Zhao, Tianhai Tian, Xinan Zhang, Qiuying Li

1. Ultraliser: a framework for creating multiscale, high-fidelity and geometrically realistic 3D models for in silico neuroscience
   Marwan Abdellah, Juan José García Cantero, Nadir Román Guerrero, Alessandro Foni, …, Pierre J. Magistretti, Henry Markram, Felix Schürmann

2. Evolution and spread of multidrug resistant pathogens in a spatially heterogeneous environment
   Quentin Griette, Matthieu Alfaro, Gaël Raoul, Sylvain Gandon

3. Allopatric divergence of cooperators confers cheating resistance and limits the effects of a defector mutation
   Kaitlin A. Schaal, Yuen-Tsu Nicco Yu, Marie Vasse, Gregory J. Velicer

4. Bernstein polynomial approximation of fixation probability in finite population evolutionary games
   Jiyeon Park, Paul Newton

5. Mutation accumulation in exponentially growing populations
   Michael D. Nicholson, David Cheek, Tibor Antal

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.

Jacob Pettit"‘s “Hot Topics in ML+Bio” newsletter showcases papers, research and news focusing on the fields of Machine Learning and ML for biology. Subscribe today!

Caption: “Are you interested in the interplay between machine learning and biology? I recently launched “Hot Topics in ML+Bio”, a weekly newsletter in which I try to collect papers and research relating to fields of Machine Learning and ML for biology. Thinking about the similarities between these two fields, I was inspired to create this artwork. The animated shape on the bottom of the screen represents the dynamic nature of a probability distribution, the grid represents a cell grid/lattice as is used in some simulations, the translucent circle and its contents is a stylized representation of a cell and its organelles, while the dot grid in the upper left is another visualization of a cell grid and the color-changing circle overlaying it represents the changing nature of a cell membrane. To make this image I used the Canva tool which has a large library of shapes and animations to pull from.”

Created by: Jacob Pettit (@pettitjf)

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

• Postdoc in Quantitative Cancer Control lab at University of California San Diego (Kit Curtius, UCSD) – Open until filled

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• 12th European Symposium 'Cancer, multicellularity and complex systems' (Lund University, Sweden) - 5-7 Sep 2022 (contact the organizers to register)

3. Special issues

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