This week in MathOnco 223
Cancer metastasis, phenotypic heterogeneity, polyaneuploid cancer cells, and agent-based modeling
“This week in Mathematical Oncology” — Aug. 18, 2022
> mathematical-oncology.org
From the editor:
Today we feature articles on cancer metastasis, phenotypic heterogeneity, polyaneuploid cancer cells, and agent-based modeling.
Enjoy,
Jeffrey West
jeffrey.west@moffitt.org
"Cancer doesn't invent anything. All the key features have a normal equivalent that is either manifested out of context or starts normally but doesn't end."
- Irina Kareva1
Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer
Meredith S. Brown, Behnaz Abdollahi, Owen M. Wilkins, Hanxu Lu, …, Mohit Kumar Jolly, Brock C. Christensen, Saeed Hassanpour, Diwakar R. PattabiramanOptimal control of two cytotoxic drug maximum tolerated dose steers and exploits cancer adaptive resistance in a cell-based framework
Matteo Italia, Fabio DercoleUnderstanding Metabolic Alterations in Cancer Cachexia through the Lens of Exercise Physiology
Irina KarevaModeling metastatic tumor evolution, numerical resolution and growth prediction
I. M. Bulai, M. C. De Bonis, C. Laurita, V. SagariaMathematical Modeling and Analysis of Tumor Chemotherapy
Ge Song, Guizhen Liang, Tianhai Tian, Xinan ZhangUntangling the web of intratumour heterogeneity
Zheqi Li, Marco Seehawer, Kornelia PolyakA life history model of the ecological and evolutionary dynamics of polyaneuploid cancer cells
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. BrownSpatially resolved clonal copy number alterations in benign and malignant tissue
Andrew Erickson, Mengxiao He, Emelie Berglund, Maja Marklund, …, Thomas Helleday, Ian G. Mills, Alastair D. Lamb, Joakim LundebergDesigning phase I oncology dose escalation using dose–exposure–toxicity models as a complementary approach to model-based dose–toxicity models
Kristyn Pantoja, Shankar Lanke, Alain Munafo, Anja Victor, Christina Habermehl, Armin Schueler, Karthik Venkatakrishnan, Pascal Girard, Kosalaram GotetiSpatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients
Hua-Jun Wu, Daniel Temko, Zoltan Maliga, Andre L. Moreira, …, Erin H. Seeley, Nicholas Navin, Robert J. Downey, Franziska Michor
The sum and the parts: dynamics of multiple and individual metastases during adaptive therapy
Jill A. Gallaher, Maximilian Strobl, Jeffrey West, Jingsong Zhang, Robert A. Gatenby, Mark Robertson-Tessi, Alexander R. A. Anderson
How researchers created complex tiling patterns with bioengineered bacteria
Nature Video
Sara Reardon: “How researchers created complex tiling patterns with bioengineered bacteria”
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Caption: “The sum and the parts. This image shows how multiple distinct metastases respond to an adaptive therapy regimen. In our off-lattice, multi-domain, agent-based model, we grow and treat different sets of tumors with variation in the total burden, number of metastases, proliferation rates, drug resistance, cell turnover, heterogeneity, and seeding. We show how a single cycle of adaptive therapy can be used as a tool to infer different traits from tumor dynamics. Read our preprint here.”
Created by: Jill Gallaher
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