This week in MathOnco 252

Selection, adaptive immunity, adaptive therapy, cellular barcoding, and combination therapy.

“This week in Mathematical Oncology” — May 4, 2023

> mathematical-oncology.org

From the editor:

What a great week in sunny Phoenix at the MathOnc23 meeting — catch up on the talks & discussion by following the hashtag #MathOnc23.

Today we feature articles on model selection, adaptive immunity, adaptive therapy, cellular barcoding, and combination therapy.

Thanks,

Jeffrey West
jeffrey.west@moffitt.org

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“We should stop acting as if our goal is to author extremely elegant theories, and instead embrace complexity and make use of the best ally we have: the unreasonable effectiveness of data.”
―Peter Norvig

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1. Myeloid-Derived Suppressor–Cell Dynamics Control Outcomes in the Metastatic Niche
   Jesse Kreger, Evanthia T. Roussos Torres, Adam L. MacLean

2. Assessing the identifiability of model selection frameworks for the prediction of patient outcomes in the clinical breast cancer setting
   C.M. Phillips, E.A.B.F. Lima, C. Wu, A.M. Jarrett, Z. Zhou, N. Elshafeey, J. Ma, G.M. Rauch, T.E. Yankeelov

3. Calibrating agent-based models to tumor images using representation learning
   Colin G. Cess,Stacey D. Finley

4. A multispecies framework for modeling adaptive immunity and immunotherapy in cancer
   Timothy Qi, Benjamin Vincent, Yanguang Cao

5. Exploiting convergent phenotypes to derive a pan-cancer cisplatin response gene expression signature
   Jessica A. Scarborough, Steven A. Eschrich, Javier Torres-Roca, Andrew Dhawan & Jacob G. Scott

6. Cellular barcoding tracks heterogeneous clones through selective pressures and phenotypic transitions
   Kennedy K. Howland, Amy Brock

1. Additivity predicts the efficacy of most approved combination therapies for advanced cancer
   Haeun Hwangbo, Sarah Patterson, Andy Dai, Deborah Plana, Adam C. Palmer

2. Learning to Adapt - Deep Reinforcement Learning in Treatment-Resistant Prostate Cancer
   Kit Gallagher, Maximilian Strobl, Robert Gatenby, Philip Maini, Alexander Anderson

3. Gene regulatory network inference with popInfer reveals dynamic regulation of hematopoietic stem cell quiescence upon diet restriction and aging
   Megan K Rommelfanger, Marthe Behrends, Yulin Chen, Jonathan Martinez, Martin Bens, Lingyun Xiong, K Lenhard Rudolph, Adam L MacLean

4. Segment Anything in Medical Images
   Jun Ma, Bo Wang

5. A simple stochastic model for cell population dynamics in colonic crypts
   Konstantinos Mamis, Ruibo Zhang, Ivana Bozic

1. EGTtools: Evolutionary game dynamics in Python
   Elias Fernández Domingos, Francisco C. Santos, Tom Lenaerts

2. Unraveling non-genetic heterogeneity in cancer with dynamical models and computational tools
   Maalavika Pillai, Emilia Hojel, Mohit Kumar Jolly & Yogesh Goyal

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Based on the MathOnc23 conference.

Artist: Artetarian Lab

Caption: “We are excited to share this week's special artwork, which highlights the
MathOnc23 conference that just concluded. Even more exciting is that the
artist contributing this week's artwork is Dr. Kristin Swanson's very talented
daughter. Throughout the MathOnc23 conference, this young artist’s work
was shown on the screens between sessions and talks. The artwork
showcases the always impressive Sonoran Desert, where the Phoenix Mayo
Clinic resides, with surrounding mountains rising dramatically from the
desert floor. If you would like to show support for this young artist, please
visit their Artetarian Lab website to see another piece of artwork (‘The Face
of Diversity’) being used for a great cause to support very young artists! The
MathOnc23 conference was organized by conference chair Dr. Kristin
Swanson and co-chair Dr. Alexander (Sandy) Anderson and generously
funded by the NCI PSOC and CSBC programs, the J. S. McDonnell foundation,
and the Mayo Clinic Comprehensive Cancer Center.”

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

• Junior professor; tenure track (University of Montpellier) in AI and multiscale modeling in biology and bio-medicine

• Junior Chair Position: Computational modeling of omics data (Sebastien Benzekry, Inria Center of Côte d'Azur University, Marseilles)

2. Conferences / Meetings

3. Special issues

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1. H/T Andrew Krause (https://empathicdynamics.wordpress.com/2019/07/25/quotes-about-mathematical-modelling/)